Estradiol acetylsalicylate

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Estradiol acetylsalicylate
Clinical data
Other namesEstradiol 3-acetylsalicylate; Acetylsalicylate estradiol
Routes of
administration		By mouth
Drug classEstrogen; Estrogen ester
Identifiers
  • [(8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] 2-acetyloxybenzoate
JSmol)
  • CC(=O)OC1=CC=CC=C1C(=O)OC2=CC3=C(C=C2)[C@H]4CC[C@]5([C@H]([C@@H]4CC3)CC[C@@H]5O)C
  • InChI=1S/C27H30O5/c1-16(28)31-24-6-4-3-5-22(24)26(30)32-18-8-10-19-17(15-18)7-9-21-20(19)13-14-27(2)23(21)11-12-25(27)29/h3-6,8,10,15,20-21,23,25,29H,7,9,11-14H2,1-2H3/t20-,21-,23+,25+,27+/m1/s1
  • Key:KNJUTXJFANOVGR-HXVSAZQXSA-N

Estradiol acetylsalicylate, or estradiol 3-acetylsalicylate, is a

acetylsalicylic acid (aspirin) ester of estradiol – which was described in the late 1980s and was never marketed.[1][2][3][4][5] In dogs, the oral bioavailability of estradiol acetylsalicylate was found to be 17-fold higher than that of unmodified estradiol.[1][4] However, a subsequent study found that the oral bioavailability of estradiol and estradiol acetylsalicylate did not differ significantly in rats (4.3% and 4.2%, respectively), suggestive of a major species difference.[2][4][6]

See also

References

  1. ^
    S2CID 7308414
    .
  2. ^
    ISSN 0378-5173
    .
  3. ISBN 978-3-642-60107-1
    .
  4. ^
    ISBN 978-0-387-49785-3
    .
  5. ISBN 978-3-527-63318-0
    .
  6. ISSN 0378-5173
    .
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