GTP-binding protein regulators
GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in signaling pathways, which act to regulate functions of other proteins. They are active or 'ON' when it is bound to GTP and inactive or 'OFF' when bound to GDP.[1] Activation and deactivation of small GTPases can be regarded as occurring in a cycle, between the GTP-bound and GDP-bound form, regulated by other regulatory proteins.
Exchangers
The inactive form of GTPases (GDP-form) are activated by a class of proteins called
Stimulators
The rate of GTP hydrolysis for small GTPases is generally too slow to create physiologically relevant transient signals, and thus requires another class of regulatory proteins to accelerate this activity, the
Inhibitors
Another class of regulatory proteins, the
References
- ISBN 978-3-527-31397-6. Retrieved 15 December 2010.
External links
- GTP-Binding+Protein+Regulators at the U.S. National Library of Medicine Medical Subject Headings (MeSH)