GNB3
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| Location (UCSC) | Chr 12: 6.84 – 6.85 Mb | Chr 6: 124.81 – 124.82 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 is a protein that in humans is encoded by the GNB3 gene.[5][6]
Heterotrimeric guanine nucleotide-binding proteins ( G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000111664 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023439 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 21235423.
- PMID 16600389.
- ^ "Entrez Gene: GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3".
Further reading
- Wedegaertner PB, Wilson PT, Bourne HR (1995). "Lipid modifications of trimeric G proteins". J. Biol. Chem. 270 (2): 503–6. PMID 7822269.
- Downes GB, Gautam N (2000). "The G protein subunit gene families". Genomics. 62 (3): 544–52. PMID 10644457.
- Sartori M, Parotto E, Ceolotto G, et al. (2005). "[C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk]". Ann. Ital. Med. Int. 19 (4): 240–8. PMID 15678704.
- Zhu H, Wang X, Lu Y, et al. (2006). "Update on G-protein polymorphisms in hypertension". Curr. Hypertens. Rep. 8 (1): 23–9. S2CID 26945864.
- Weder AB (2007). "Genetics and hypertension" (PDF). Journal of Clinical Hypertension (Greenwich, Conn.). 9 (3): 217–23. S2CID 10559655.
- Levine MA, Modi WS, O'Brien SJ (1991). "Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man". Genomics. 8 (2): 380–6. PMID 1979057.
- Levine MA, Smallwood PM, Moen PT, et al. (1990). "Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2329–33. PMID 2107550.
- Garcia-Higuera I, Thomas TC, Yi F, Neer EJ (1996). "Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma". J. Biol. Chem. 271 (1): 528–35. PMID 8550614.
- Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. PMID 8636150.
- Ansari-Lari MA, Muzny DM, Lu J, et al. (1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res. 6 (4): 314–26. PMID 8723724.
- Ansari-Lari MA, Shen Y, Muzny DM, et al. (1997). "Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination". Genome Res. 7 (3): 268–80. PMID 9074930.
- Siffert W, Rosskopf D, Siffert G, et al. (1998). "Association of a human G-protein beta3 subunit variant with hypertension". Nat. Genet. 18 (1): 45–8. S2CID 10239855.
- Kageyama K, Murakami T, Iizuka K, et al. (1999). "Translocation of G-protein beta3 subunit from the cytosol pool to the membrane pool by beta1-adrenergic receptor stimulation in perfused rat hearts". Biochem. Pharmacol. 58 (9): 1497–500. PMID 10513993.
- Rosskopf D, Busch S, Manthey I, Siffert W (2000). "G protein beta 3 gene: structure, promoter, and additional polymorphisms". Hypertension. 36 (1): 33–41. PMID 10904009.
- Obineche EN, Frossard PM, Bokhari AM (2002). "An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs". Hypertens. Res. 24 (6): 635–9. PMID 11768721.
- Tabara Y, Kohara K, Miki T (2002). "Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension". J. Hypertens. 20 (4): 651–6. S2CID 22407752.
- Serretti A, Lorenzi C, Lilli R, et al. (2002). "Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants". Am. J. Med. Genet. 114 (4): 370–9. PMID 11992559.
- Shlyakhto EV, Shwartz EI, Nefedova YB, et al. (2002). "Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension". Med. Sci. Monit. 8 (5): CR337–40. PMID 12011775.
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