Granuloma inguinale

Source: Wikipedia, the free encyclopedia.
Not to be confused with Granuloma annulare.
This article is about the ulcerative disease caused by Klebsiella granulomatis. For the sexually transmitted infection caused by certain types of chlamydia, see Lymphogranuloma venereum.
Granuloma inguinale
Other namesDonovanosis
Donovanosis
SpecialtyInfectious diseases, dermatology Edit this on Wikidata

Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis)[1] characterized by genital ulcers.[2] It is endemic in many less-developed regions. It is also known as donovanosis,[3] granuloma genitoinguinale,[3] granuloma inguinale tropicum,[3] granuloma venereum,[4] granuloma venereum genitoinguinale,[3] lupoid form of groin ulceration,[3] serpiginous ulceration of the groin,[3] ulcerating granuloma of the pudendum,[3] and ulcerating sclerosing granuloma. Oral manifestations are also notably seen. The lesions of oral cavity are usually secondary to active genital lesions.

The disease often goes untreated because of the scarcity of medical treatment in the countries in which it is found. In addition, the painless

vascular lesions. The destructive nature of donovanosis also increases the risk of superinfection by other pathogenic
microbes.

Symptoms and signs

Granulome inguinale on a vulva

Small, painless nodules appear after about 10–40 days of contact with the bacteria. Later, the nodules burst, creating open, fleshy red ulcers with rolled edges that have a tendency to bleed on contact. The

labia, or the perineum, and in the oral region due to oral intercourse. Rarely, the vaginal wall or cervix is the site of the lesion. At least one case in India led to partial autoamputation of the penis. The patient tested positive for HIV-2 and had been infected for six years.[6]
Genital elephantiasis can occur because of the blockage of the lymphatic channels due to scarring of the ulcers. There is concern that there's a linkage between donovanosis and squamous cell carcinoma [7]

Mechanism

The microorganism spreads from one host to another through contact with the open sores.[8]

Diagnosis

The

mononuclear phagocytes or histiocytes in tissue samples from patients with granuloma inguinale.[9]

They appear deep purple when stained with

intracellular inclusions are the encapsulated Gram-negative rods of the causative organisms.[9] They were discovered by Charles Donovan.[10]

Classification

The first known name for this condition was "serpiginous ulcer", which dates to 1882.[11][12] The proper clinical designation for donovanosis is "granuloma inguinale".[5] A granuloma is a nodular type of inflammatory reaction, and inguinale refers to the inguinal region, which is commonly involved in this infection. The disease is commonly known as donovanosis, after the Donovan bodies seen on microscopy, which are a diagnostic sign.[13]

The causative organism, Klebsiella granulomatis, was called Calymmatobacterium granulomatis, and some sources still use this classification,[14][15] from the Greek kalymma (a hood or veil), referring to the lesions that contain the bacteria. Prior to this, it was called Donovania granulomatis, named after the Donovan bodies.[5]

The

taxonomic change since it involved changing the organism's phylum. However, polymerase chain reaction techniques using a colorimetric detection system showed a 99% similarity with other species in the genus Klebsiella.[17] The clinical appearances of this lesion orally are classified into three types: Ulcerative, exuberant, cicatricial.[18]

Prevention

The disease is effectively treated with

developed countries have a very low incidence of donovanosis; about 100 cases are reported each year in the United States. However, sexual contact with individuals in endemic regions dramatically increases the risk of contracting the disease. Using condoms, sexually transmitted infection testing before beginning a sexual relationship, and avoidance of these sexual contacts are effective preventative measures for donovanosis.[19]

Treatment

Recommended regimen is

trimethoprim-sulfamethoxazole one double-strength (160 mg/800 mg) tablet orally twice a day. All antibiotic regimens should last for at least 3 weeks and until all lesions have completely healed. Association with gentamicin is sometimes used in severe cases, specially in cases of AIDS. Normally, the infection will begin to subside within a week of treatment, but the full treatment period must be followed to minimize the possibility of relapse.[citation needed
] Sporadic surgical ressection of the lesions has been used in extensive perineal fistulae refractory to pharmacological intervention. The CDC 2015 guidelines give azithromycin as the antibiotic of choice.[20]

See also

References

  1. PMID 12473810
    .
  2. ISBN 978-0-7020-7870-5
    .
  3. ^
    ISBN 978-1-4160-2999-1
    .
  4. ISBN 978-0-7216-2921-6
    .
  5. ^
    ISBN 978-0-323-03303-9
    .
  6. PMID 19052412
    .
  7. ^ Arora AK, Kumaran MS, Narang T, et al. Donovanosis and squamous cell carcinoma: the relationship conundrum! Int J STD AIDS. 2017;28:411–414.
  8. ^ "Granuloma Inguinale (Donovanosis)".
  9. ^ a b c thefreedictionary.com > Donovan bodies Retrieved on Nov 29, 2009
  10. PMID 29004684
    .
  11. PMID 17459300
    .
  12. PMID 28997806
    .
  13. PMID 30020678
    . Retrieved 12 July 2021.
  14. ^ "granuloma inguinale" at Dorland's Medical Dictionary
  15. PMID 12473810
    .
  16. PMID 12635932
    .
  17. PMID 10555350
    .
  18. ^ "Donovanosis". The Lecturio Medical Concept Library. Retrieved 12 July 2021.
  19. ^ "Granuloma Inguinale". MSD. Retrieved 12 July 2021.
  20. ^ "Granuloma Inguinale (Donovanosis) - 2015 STD Treatment Guidelines". www.cdc.gov. Retrieved 2018-08-23.

Further reading

  • Gavin Hart MD, MPH Transcript of the lecture given at the Australian Society for Infectious Diseases/Australasian College of Tropical Medicine Conference at Palm Cove (Cairns), Queensland on 19 April 1999.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Granuloma_inguinale&oldid=1202460822"