Ipodate sodium

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Ipodate sodium
Clinical data
Routes of
administration		oral, Intravenous
ATC code
Identifiers
  • sodium 3-(3-{[(dimethylamino)methylidene]amino}-2,4,6-triiodophenyl)propanoate
JSmol)
Melting point168–169 °C (334–336 °F)
  • CN(C)/C=N/c1c(cc(c(c1I)CCC(=O)[O-])I)I.[Na+]
  • InChI=1S/C12H13I3N2O2.Na/c1-17(2)6-16-12-9(14)5-8(13)7(11(12)15)3-4-10(18)19;/h5-6H,3-4H2,1-2H3,(H,18,19);/q;+1/p-1/b16-6+;
  • Key:ZFHZUGUCWJVEQC-FPUQOWELSA-M

Ipodate sodium (sodium iopodate) is an

contrast media used for X-rays
. The drug is given orally and the resulting contrast allows for easy resolution of the bile duct and gall bladder.

Other uses

Although not FDA approved, ipodate sodium has been used to treat Graves' disease and thyroid storm, an extreme form of hyperthyroidism.

Graves' disease

Long-term treatment of Graves' disease with ipodate sodium (500 mg, daily) given by mouth reduced levels of

T4 in the patients.[1]
This was done with minimal side effects, indicating possible clinical usefulness. Iodine uptake was also noted to return to normal within seven days, indicating control with ipodate with rapid follow up treatment with 131I is feasible.

Thyroid storm

In emergency situations, ipodate can be administered for

T4 levels back down. Ipodate also inhibits the conversion of T4 to T3 (which is more potent). It is not considered a first-line approach, as potassium iodide and beta blockers
have less potential for side-effects. Ipodate sodium lacks FDA approval for this use.

References

  1. PMID 3928675
    .
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