MT-TW
| mitochondrially encoded tRNA tryptophan | |
|---|---|
| Identifiers | |
| Symbol | MT-TW |
| Alt. symbols | MTTW |
Chr. MT [1] | |
Mitochondrially encoded tRNA tryptophan also known as MT-TW is a transfer RNA which in humans is encoded by the mitochondrial MT-TW gene.[1]
Structure
The MT-TW gene is located on the
tRNA molecule is a distinctive folded structure which contains three hairpin loops and resembles a three-leafed clover.[3]
Function
MT-TW is a small 68 nucleotide
translation
.
Clinical significance
Mutations in MT-TW have been associated with
seizures.[5]
Changes in MT-TW which impair oxidate phosphorylation also cause
seizures, and other problems affecting the nervous system.[6] Variants of the gene which cause the disease have included 5556G-A,[7] 5545C-T,[8] and 5521G-A.[9]
References
- S2CID 4355527.
- ^ "MT-TW mitochondrially encoded tRNA tryptophan [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ^ "tRNA / transfer RNA". Learn Science at Scitable.
- ^ Reference, Genetics Home. "Leigh syndrome". Genetics Home Reference.
This article incorporates text from this source, which is in the public domain.
- PMID 12776230.
- ^ Reference, Genetics Home. "MELAS". Genetics Home Reference.
- PMID 19809478.
- PMID 18337306.
- S2CID 30541304.
External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.