MT-TY
| mitochondrially encoded tRNA tyrosine | |
|---|---|
| Identifiers | |
| Symbol | MT-TY |
| Alt. symbols | MTTY |
Chr. MT [1] | |
Mitochondrially encoded tRNA tyrosine, also known as MT-TY, is a transfer RNA which in humans is encoded by the mitochondrial MT-TY gene.[1]
Structure
The MT-TY gene is located on the
tRNA molecule is a distinctive folded structure which contains three hairpin loops and resembles a three-leafed clover.[3]
Function
MT-TY is a small 66 nucleotide
translation
.
Clinical significance
Mutations in MT-TY have been associated with mitochondrial complex III deficiency, a genetic condition that can affect several parts of the body, including the
skeletal muscles. Common clinical manifestations include muscle weakness (myopathy) and extreme tiredness (fatigue), particularly during exercise (exercise intolerance). Additional symptoms may also arise depending on the severity of the condition.[4] A patient with a mutation of the gene exhibited complex III deficiency, characterized by high levels of cytochrome c oxidase–deficient fibers with symptoms of weakness and fatigue.[5] A 5874A-G mutation was also found in a patient with the condition.[6]
Changes in MT-TY may also result in progressive external
have been associated with the disease.References
- S2CID 4355527.
- ^ "MT-TY mitochondrially encoded tRNA tyrosine [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov.
- ^ "tRNA / transfer RNA". Learn Science at Scitable.
- ^ Reference, Genetics Home. "Mitochondrial complex III deficiency". Genetics Home Reference.
- PMID 17846276.
- S2CID 28303519.
- ^ Reference, Genetics Home. "Progressive external ophthalmoplegia". Genetics Home Reference.
- S2CID 35762588.
- PMID 11594340.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.