Neuropeptide VF precursor
| Neuropeptide VF precursor | |
|---|---|
| Identifiers | |
| Symbol | NPVF |
| Alt. symbols | RPFP |
| HGNC | 13782 |
Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a
propeptide that in mammals is encoded by the NPVF (or RPFP) gene. The NPVF gene, and thus the propeptide, are expressed in neurons in the mediobasal hypothalamus.[1] The propeptide is cleaved to form three other peptides, which are:[2][3]
- NPFF2 receptors (EC50= 29 nM and 0.0011 nM, respectively)
- NPFF receptors; no known biological activity
- Neuropeptide VF (NPVF) (RFRP-3) – agonist of the NPFF1 receptor (IC50 = 0.7 nM)
NPSF and NPVF, originally referred to as the
RFamide-related peptides RFRP-1 and RFRP-3, respectively,[4] are the mammalian homologs of the avian neuropeptide gonadotropin-inhibitory hormone (GnIH).[2] The mammalian NPVF and avian GnIH genes, along with their aforementioned peptide products, were discovered concurrently in 2000.[1][2] Similarly to the avian GnIH neuropeptide, NPSF and NPVF have been found to potently inhibit gonadotropin secretion.[5] Moreover, a potent and selective antagonist of the NPFF receptors, RF9, has been reported to possess "very strong" gonadotropin-releasing effects in vivo in male and female mice.[6]
See also
- Neuropeptide FF
- FMRFamide
- Gonadotropin-releasing hormone
- Gonadotropin-inhibitory hormone
- Gonadotropin release inhibitor
- Kisspeptin
References
Further reading
- Ubuka, Takayoshi; Son, You Lee; Tsutsui, Kazuyoshi (2016). "Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone". General and Comparative Endocrinology. 227: 27–50. PMID 26409890.