Phosphopantothenate—cysteine ligase
| Phosphopantothenate—cysteine ligase | |||||||||
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| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In
pantothenate to Coenzyme A
. The reaction is:
- NTP + (R)-4'-phosphopantothenate + L-cysteine NMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine
The
isoform uses adenosine triphosphate (ATP).[1]
Nomenclature
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide syntheses). The systematic name of this enzyme class is (R)-4'-phosphopantothenate:L-cysteine ligase. This enzyme is also called phosphopantothenoylcysteine synthetase.
Gene
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Phosphopantothenoylcysteine synthetase in humans is encoded by the PPCS gene.[6]
Protein structure
As of late 2007, 5
structures have been solved for this class of enzymes, with PDB accession codes 1P9O, 1U7U, 1U7W, 1U7Z, and 1U80
.
References
- PMID 12906824.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127125 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028636 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Phosphopantothenoylcysteine synthetase".
Further reading
- Brown GM (1959). "The metabolism of pantothenic acid". J. Biol. Chem. 234 (2): 370–8. PMID 13630913.
- Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP (2001). "Phosphopantothenoylcysteine synthetase from Escherichia coli Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria". J. Biol. Chem. 276 (17): 13513–6. PMID 11278255.
- Kupke T (2002). "Molecular characterization of the 4'-phosphopantothenoylcysteine synthetase domain of bacterial dfp flavoproteins". J. Biol. Chem. 277 (39): 36137–45. PMID 12140293.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Phosphopantothenate—cysteine ligase
