Polyglutamylation
Polyglutamylation is a form of reversible posttranslational modification of
carboxy group can now be extended into a polyglutamate chain.[1] The glutamylation is done by the enzyme glutamylase and removed by deglutamylase
.
Polyglutamylation of chain length of up to six occurs in certain glutamate residues near the C terminus of most major forms of tubulins. These residues, though themselves not involved in direct binding, cause conformational shifts that regulate binding of microtubule associated proteins (MAP and Tau) and motors.[2]
External links
References
- ^ "Polyglutamylation: mechanism". Archived from the original on 2012-07-24. Retrieved 2010-04-12.
- PMID 7522559.