Adrenalone
This article relies largely or entirely on a single source. (December 2023) |
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Pregnancy category |
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Renal | |
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JSmol) | |
Melting point | 235 to 236 °C (455 to 457 °F) (decomposes) |
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Adrenalone is an
Contraindications and interactions
Adrenalone does not stop bleeding from large blood vessels. It is not approved for systemic use. Combination with antithrombotics is not useful because they contravene the action of adrenalone.[1]
Side effects
Vasoconstriction by adrenalone may lead to local necrosis.[1]
Pregnancy and lactation
Adrenalone passes into breast milk, but adverse effects are unlikely because of its very low systemic resorption.[1]
Chemical properties
Adrenalone is a derivative of epinephrine, having the alcohol function replaced with a ketone. As a consequence, it is not
Solubility in water, ethanol and diethyl ether is low. The substance is typically used in form of the hydrochloride, a white crystalline powder which tastes bitter and slightly acidic, and is soluble in water (1:8) and 94% ethanol (1:45). The melting point of the hydrochloride is 243 °C (469 °F).[1]
Pharmacology
After local application, only traces of adrenalone are found in the blood, which is partly a consequence of the vasoconstriction caused by the drug via alpha-1 adrenergic receptors. In an (unspecified) pharmacological model,
Like epinephrine, adrenalone is metabolised by
References
- ^ ISBN 978-3-7741-9846-3.