3-oxoacyl-(acyl-carrier-protein) reductase
(Redirected from
Beta-Ketoacyl ACP reductase
)| 3-oxoacyl-[acyl-carrier-protein] reductase | |||||||||
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ExPASy NiceZyme view | | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In
enzymology, a 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) is an enzyme that catalyzes the chemical reaction
- 3-oxoacyl-[acyl-carrier-protein](ACP) + NADPH + H+ (3R)-3-hydroxyacyl-[acyl-carrier-protein](ACP) + NADP+
This enzyme belongs to the family of
polyunsaturated fatty acid
biosynthesis.
Structural studies
As of late 2007, 21
structures have been solved for this class of enzymes, with PDB accession codes 1I01, 1O5I, 1Q7B, 1Q7C, 1ULS, 1UZL, 1UZM, 1UZN, 2A4K, 2B4Q, 2C07, 2FR0, 2FR1, 2NM0, 2NTN, 2P68, 2PFF, 2PH3, 2PNF, 2UVD, and 2Z5L
.
References
- Prescott DJ, Vagelos PR (1972). "Acyl Carrier Protein". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 36. pp. 269–311. )
- Shimakata T, Stumpf PK (1982). "Purification and characterizations of beta-Ketoacyl-[acyl-carrier-protein] reductase, beta-hydroxyacyl-[acylcarrier-protein] dehydrase, and enoyl-[acyl-carrier-protein] reductase from Spinacia oleracea leaves". Arch. Biochem. Biophys. 218 (1): 77–91. PMID 6756317.
- Toomey RE, Wakil SJ (1966). "Studies on the mechanism of fatty acid synthesis. XV. Preparation and general properties of beta-ketoacyl acyl carrier protein reductase from Escherichia coli". Biochim. Biophys. Acta. 116 (2): 189–97. PMID 4381013.
