Coenzyme B
Names | |
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IUPAC name
2-[(7-mercapto-1-oxoheptyl)amino]-3-phosphonooxybutanoic acid
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Identifiers | |
3D model (
JSmol ) |
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ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C 11H 22NO 7PS | |
Molar mass | 343.333641 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Coenzyme B is a
Coenzyme B reacts with 2-methylthioethanesulfonate (methyl-Coenzyme M, abbreviated CH
3–S–CoM), to release methane in methanogenesis:[2]
- CH
3–S–CoM + HS–CoB → CH
4 + CoB–S–S–CoM
This conversion is catalyzed by the
A related conversion that utilizes both HS-CoB and HS-CoM is the reduction of fumarate to succinate, catalyzed by fumarate reductase:[3]
- HS–CoM + HS–CoB + −O
2CCH=CHCO−
2 → −O
2CCH
2–CH
2CO−
2 + CoB–S–S–CoM
Importance of Coenzyme B in Methanogenesis
Coenzyme B is an important component in the terminal step of methane biogenesis.[4] It acts as a two electron-donor to reduce coenzyme M (methyl-coenzyme) into two molecules a methane and a heterodisulfide.[5] Two separate experiment that were performed, one with coenzyme B and other without coenzyme B, indicated that using coenzyme B before the formation of the methane molecule, results in a more efficient and consistent bond cleavage.[6]
References
- PMID 3086878.
- PMID 9782487.
- PMID 9578488.
- PMID 21090696.[permanent dead link]
- PMID 20707311.
- PMID 11669624.[permanent dead link]