DNA repair-deficiency disorder
DNA repair-deficiency disorder | |
---|---|
Specialty | Endocrinology |
A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair.
DNA repair defects and accelerated aging
DNA repair defects are seen in nearly all of the diseases described as
Human disorders with accelerated aging
- Ataxia-telangiectasia
- Bloom syndrome
- Cockayne syndrome
- Fanconi anemia
- Progeria (Hutchinson–Gilford progeria syndrome)
- Rothmund–Thomson syndrome
- Trichothiodystrophy
- Werner syndrome
- Xeroderma pigmentosum
Examples
Some examples of DNA repair defects causing progeroid syndromes in humans or mice are shown in Table 1.
Protein | Pathway | Description |
---|---|---|
ATR | Nucleotide excision repair[1] | deletion of ATR in adult mice leads to a number of disorders including hair loss and graying, kyphosis, osteoporosis, premature involution of the thymus, fibrosis of the heart and kidney and decreased spermatogenesis[2] |
DNA-PKcs | Non-homologous end joining | shorter lifespan, earlier onset of aging related pathologies;[3][4] higher level of DNA damage persistence[5] |
ERCC1 | Nucleotide excision repair, Interstrand cross link repair[6] | deficient transcription coupled NER with time-dependent accumulation of transcription-blocking damages;[7] mouse life span reduced from 2.5 years to 5 months;[8]) Ercc1−/− mice are leukopenic and thrombocytopenic, and there is extensive adipose transformation of the bone marrow, hallmark features of normal aging in mice[6] |
ERCC2 (XPD) | Nucleotide excision repair (also transcription as part of TFIIH) | some mutations in ERCC2 cause Cockayne syndrome in which patients have segmental progeria with reduced stature, intellectual disability, cachexia (loss of subcutaneous fat tissue), sensorineural deafness, retinal degeneration, and calcification of the central nervous system; other mutations in ERCC2 cause trichothiodystrophy in which patients have segmental progeria with brittle hair, short stature, progressive cognitive impairment and abnormal face shape; still other mutations in ERCC2 cause xeroderma pigmentosum (without a progeroid syndrome) and with extreme sun-mediated skin cancer predisposition[9] |
ERCC4 (XPF) | Nucleotide excision repair, Interstrand cross link repair, Single-strand annealing, Microhomology-mediated end joining[6] | mutations in ERCC4 cause symptoms of accelerated aging that affect the neurologic, hepatobiliary, musculoskeletal, and hematopoietic systems, and cause an old, wizened appearance, loss of subcutaneous fat, liver dysfunction, vision and hearing loss, chronic kidney disease, muscle wasting, osteopenia, kyphosis and cerebral atrophy[6] |
ERCC5 (XPG) | Nucleotide excision repair,[10] Homologous recombinational repair,[11] Base excision repair[12][13] | mice with deficient ERCC5 show loss of subcutaneous fat, kyphosis, osteoporosis, retinal photoreceptor loss, liver aging, extensive neurodegeneration, and a short lifespan of 4–5 months |
ERCC6 (Cockayne syndrome B or CS-B)
|
Nucleotide excision repair [especially transcription coupled repair (TC-NER) and interstrand crosslink repair] | premature aging features with shorter life span and photosensitivity, 5-hydroxycytosine and cyclopurines[15]
|
ERCC8 (Cockayne syndrome A or CS-A) | Nucleotide excision repair [especially transcription coupled repair (TC-NER) and interstrand crosslink repair] | premature aging features with shorter life span and photosensitivity, 5-hydroxycytosine and cyclopurines[15]
|
GTF2H5 (TTDA) | Nucleotide excision repair | deficiency causes trichothiodystrophy (TTD) a premature-ageing and neuroectodermal disease; humans with GTF2H5 mutations have a partially inactivated protein[16] with retarded repair of 6-4-photoproducts[17] |
Ku70 | Non-homologous end joining | shorter lifespan, earlier onset of aging related pathologies;[18] persistent foci of DNA double-strand break repair proteins[19] |
Ku80 | Non-homologous end joining | shorter lifespan, earlier onset of aging related pathologies;[20] defective repair of spontaneous DNA damage[18] |
Lamin A
|
Non-homologous end joining, Homologous recombination | increased DNA damage and chromosome aberrations; progeria; aspects of premature aging; altered expression of numerous DNA repair factors[21] |
NRMT1 | Nucleotide excision repair[22] | mutation in NRMT1 causes decreased body size, female-specific infertility, kyphosis, decreased mitochondrial function, and early-onset liver degeneration[23] |
RECQL4 | Base excision repair, Nucleotide excision repair, Homologous recombination, Non-homologous end joining[24] | mutations in RECQL4 cause Rothmund-Thomson syndrome, with alopecia, sparse eyebrows and lashes, cataracts and osteoporosis[24] |
SIRT6
|
Base excision repair, Nucleotide excision repair, Homologous recombination, Non-homologous end joining [25] | SIRT6-deficient mice develop profound lymphopenia, loss of subcutaneous fat and lordokyphosis, and these defects overlap with aging-associated degenerative processes[26] |
SIRT7
|
Non-homologous end joining | mice defective in SIRT7 show phenotypic and molecular signs of accelerated aging such as premature pronounced curvature of the spine, reduced life span, and reduced non-homologous end joining[27] |
Werner syndrome helicase | Homologous recombination,[28][29] Non-homologous end joining,[30]Base excision repair,[31][32] Replication arrest recovery[33] | shorter lifespan, earlier onset of aging related pathologies, genome instability[34][35] |
ZMPSTE24 | Homologous recombination | lack of Zmpste24 prevents lamin A formation and causes progeroid phenotypes in mice and humans, increased DNA damage and chromosome aberrations, sensitivity to DNA-damaging agents and deficiency in homologous recombination[36] |
DNA repair defects distinguished from "accelerated aging"
Most of the DNA repair deficiency diseases show varying degrees of "accelerated aging" or cancer (often some of both).[37] But elimination of any gene essential for base excision repair kills the embryo—it is too lethal to display symptoms (much less symptoms of cancer or "accelerated aging").[38] Rothmund-Thomson syndrome and xeroderma pigmentosum display symptoms dominated by vulnerability to cancer, whereas progeria and Werner syndrome show the most features of "accelerated aging".
Debate concerning "accelerated aging"
Some biogerontologists question that such a thing as "accelerated aging" actually exists, at least partly on the grounds that all of the so-called accelerated aging diseases are segmental progerias. Many disease conditions such as diabetes, high blood pressure, etc., are associated with increased mortality. Without reliable biomarkers of aging it is hard to support the claim that a disease condition represents more than accelerated mortality.[42]
Against this position other biogerontologists argue that premature aging
DNA repair defects and increased cancer risk
Individuals with an inherited impairment in DNA repair capability are often at increased risk of cancer.[45] When a mutation is present in a DNA repair gene, the repair gene will either not be expressed or be expressed in an altered form. Then the repair function will likely be deficient, and, as a consequence, damages will tend to accumulate. Such DNA damages can cause errors during DNA synthesis leading to mutations, some of which may give rise to cancer. Germ-line DNA repair mutations that increase the risk of cancer are listed in the Table.
DNA repair gene | Protein | Repair pathways affected | Cancers with increased risk |
---|---|---|---|
breast cancer 1 & 2 | BRCA1 BRCA2 | HRR of double strand breaks and daughter strand gaps[46] | breast, ovarian [47] |
ataxia telangiectasia mutated
|
ATM
|
Different mutations in ATM reduce HRR, SSA or NHEJ [48] | leukemia, lymphoma, breast [48][49] |
Nijmegen breakage syndrome | NBS (NBN) | NHEJ [50] | lymphoid cancers [50] |
MRE11A | MRE11 | HRR and NHEJ [51] | breast [52] |
Bloom syndrome | BLM (helicase) | HRR [53] | leukemia, lymphoma, colon, breast, skin, lung, auditory canal, tongue, esophagus, stomach, tonsil, larynx, uterus [54] |
WRN
|
WRN | HRR, NHEJ, long patch BER [55] | soft tissue sarcoma, colorectal, skin, thyroid, pancreas [56] |
RECQL4 | RECQ4 | Helicase likely active in HRR [57] | basal cell carcinoma, squamous cell carcinoma, intraepidermal carcinoma [58] |
Fanconi anemia genes FANCA, B, C, D1, D2, E, F, G, I, J, L, M, N | FANCA etc. | HRR and TLS [59] | leukemia, liver tumors, solid tumors many areas [60] |
XPC, XPE (DDB2) | XPC, XPE | Global genomic NER, repairs damage in both transcribed and untranscribed DNA [61][62] | skin cancer (melanoma and non-melanoma) [61][62] |
XPA, XPB, XPD, XPF, XPG | XPA XPB XPD XPF XPG | transcribed strands of transcriptionally active genes [63]
|
skin cancer (melanoma and non-melanoma) [63] |
XPV (also called polymerase H)
|
XPV (POLH) | Translesion synthesis (TLS) [64] | skin cancers (basal cell, squamous cell, melanoma) [64] |
mutS (E. coli) homolog 2, mutS (E. coli) homolog 6, mutL (E. coli) homolog 1,
postmeiotic segregation increased 2 (S. cerevisiae) |
MSH2 MSH6 MLH1 PMS2 | MMR [65] | colorectal, endometrial [65] |
mutY homolog (E. coli) | MUTYH | BER of A paired with 8-oxo-dG [66] | colon [66] |
TP53 | P53 | Direct role in HRR, BER, NER and acts in DNA damage response[67] for those pathways and for NHEJ and MMR [68] | sarcomas, breast cancers, brain tumors, and adrenocortical carcinomas [69] |
NTHL1 | NTHL1 | BER for Tg, FapyG, 5-hC, 5-hU in dsDNA[70] |
See also
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External links
- BRCA - Companion Reviews and Search Terms
- BRCA1 - Companion Reviews and Search Terms
- BRCA2 - Companion Reviews and Search Terms
- ATM - Companion Reviews and Search Terms
- NBS1 - Companion Reviews and Search Terms
- Bloom s syndrome - Companion Reviews and Search Terms
- Fanconi s anemia - Companion Reviews and Search Terms
- WRN - Companion Reviews and Search Terms
- RECQ- Companion Reviews and Search Terms
- RECQL4 - Companion Reviews and Search Terms
- FANCJ - Companion Reviews and Search Terms
- FANCM - Companion Reviews and Search Terms
- FANCN - Companion Reviews and Search Terms
- XPB - Companion Reviews and Search Terms
- XPD - Companion Reviews and Search Terms
- XPG - Companion Reviews and Search Terms
- MSH6 - Companion Reviews and Search Terms
- MUTYH - Companion Reviews and Search Terms
- DNA repair and toxicology - Companion Reviews and Search Terms
- Neoplasia inherited - Companion Reviews and Search Terms
- Neoplasia carcinogenesis - Companion Reviews and Search Terms
- Segmental Progeria