Mastadenovirus

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Mastadenovirus
Virus classification Edit this classification
(unranked): Virus
Realm: Varidnaviria
Kingdom: Bamfordvirae
Phylum: Preplasmiviricota
Class: Tectiliviricetes
Order: Rowavirales
Family: Adenoviridae
Genus: Mastadenovirus
Species

see text

Mastadenovirus is a genus of

viruses in the family Adenoviridae
. Humans and other mammals serve as natural hosts. There are 51 species in this genus. The genus as a whole includes many very common causes of human infection, estimated to be responsible for 2 to 5% of all respiratory infections, as well as gastrointestinal and eye infections. Symptoms are usually mild.

Specific tropisms include: serotypes 3, 5, and 7: lower respiratory tract infections, serotypes 8, 19, and 37: epidemic keratoconjunctivitis, serotypes 4 and 7: acute respiratory disease, serotypes 40 and 41: gastroenteritis, serotype 14: can cause potentially fatal adenovirus infections.[citation needed]

Canine mastadenovirus A (formerly canine adenovirus-1, CAdV-1) can lead to death in puppies, or encephalitis in other carnivore species.[1][2][3]

Etymology

The name Mastadenovirus is derived from the Greek word mastos 'breast' (hence mammal) and adenovirus, named for the human adenoids, which the virus was first isolated from.[4][5]

Taxonomy

The genus contains the following species:[6]

Human serotypes

Main article: Adenoviridae § Diversity

Structure

Viruses in Mastadenovirus are

icosahedral geometries, and T=25 symmetry. The diameter is around 90 nm. Genomes are linear and non-segmented, around 35-36kb in length. The genome codes for 40 proteins.[1][7]

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Mastadenovirus Polyhedral Pseudo T=59 Non-enveloped Linear Monopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral fibers to the host CAR adhesion receptor. Subsequent binding of the penton protein to host integrin entry receptors mediates internalization into the host cell by

ribosomal shunting. The virus exits the host cell by nuclear envelope breakdown, viroporins
, and lysis. Human, mammals, and vertebrates serve as the natural host. Transmission routes are fecal-oral and respiratory. [1]

Genus Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Mastadenovirus Humans; mammals None Glycoprotiens Lysis Nucleus Nucleus Unknown

References

  1. ^ a b c "Viral Zone". ExPASy. Retrieved 1 July 2015.
  2. ^ ICTV. "Virus Taxonomy: 2014 Release". Retrieved 1 July 2015.
  3. ^ taxonomy. "Taxonomy browser (Mastadenovirus)". Ncbi.nlm.nih.gov. Retrieved 16 January 2014.
  4. S2CID 3097955
    .
  5. PMID 14431746
    .
  6. ^ "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 22 May 2021.
  7. PMID 30778154
    .

External links