Methdilazine

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Methdilazine
Clinical data
AHFS/Drugs.comMonograph
ATC code
Identifiers
  • 10-[(1-methylpyrrolidin-3-yl) methyl]- 10H-phenothiazine
JSmol)
  • S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 checkY
  • Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Methdilazine (Dilosyn, Tacaryl) is a

first-generation antihistamine with anticholinergic properties of the phenothiazine
class.

Synthesis

Mead Johnson & Company; U.S. patent 2,945,855
(1960).

See also

References

  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).
  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100.
    PMID 15782943
    .
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6.
    PMID 9700532
    .
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72.
    PMID 2905130
    .

The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.