Parkinson-plus syndrome

Source: Wikipedia, the free encyclopedia.
Parkinson-plus syndromes
Other namesDisorders of multiple system degeneration
SpecialtyNeurology

Parkinson-plus syndromes (PPS) are a group of neurodegenerative

idiopathic Parkinson's disease (PD). Parkinson-plus syndromes are either inherited genetically or occur sporadically.[2][3]

Atypical parkinsonism and other Parkinson-plus syndromes are often difficult to differentiate from PD and each other. They include

tauopathies.[4][5] They may coexist with other pathologies.[6]

Additional Parkinson-plus syndromes include

Presentation

Clinical features that distinguish Parkinson-plus syndromes from idiopathic PD include symmetrical onset, a lack of or irregular

pyramidal cells, and in some instances significant cognitive impairment.[2]

Diagnosis

Accurate diagnosis of these Parkinson-plus syndromes is improved when precise diagnostic criteria are used.

SPECT procedure using 123Iiodobenzamide (IBZM), is an effective tool in the establishment of the differential diagnosis between patients with PD and Parkinson-plus syndromes.[9]

Treatments

Parkinson-plus syndromes are usually more rapidly progressive and less likely to respond to antiparkinsonian medication than PD.[10][11] However, the additional features of the diseases may respond to medications not used in PD.[citation needed]

Current therapy for Parkinson-plus syndromes is centered around a multidisciplinary treatment of symptoms.[12][13]

See also

References

External links