Small nucleolar RNA SNORD113

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Small nucleolar RNA SNORD113/SNORD114 family
GO
GO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In

epigenetic imprinting process.[1]

In humans the imprinted domain at 14q32 contains two clusters of tandemly repeated small nucleolar RNAs named 14q(I) and 14q(II) snoRNAs. These two clusters contain 9 and 31 highly related snoRNAs respectively. These two related snoRNAs are known as SNORD113 and SNORD114 respectively in the

MEG8
RNA, which lies downstream of the imprinted genes DLK1 and GTL2.

SNORD113 and SNORD114 belong to the

SnRNA
. As a result, they are not predicted to guide to 2'O-methylation of a rRNA or snRNA.

Homologues of SNORD113 and SNORD114 are found in the imprinted non-coding mouse transcript Rian where they are again found in tandem array of 9 highly related snoRNAs. These snoRNAs also display tissue specific (brain) expression. C/D box snoRNAs were also identified in the rat non-coding Bsr (brain-specific repetitive) RNA.

Another imprinted human locus 15q11q13 encodes tandemly repeated C/D box snoRNA genes which are expressed only from the paternal

Prader-Willi syndrome.[3][4][5][6][7] A possible role for tandemly repeated C/D snoRNA genes in the evolution and/or mechanism of the epigenetic imprinting process has been suggested.[1]

References

  1. ^
    PMID 12045206
    .
  2. PMID 12215523
    .
  3. PMID 18166085
    .
  4. PMID 18500341
    .
  5. PMID 18320030
    .
  6. S2CID 12256515
    .
  7. PMID 19498035
    .

External links


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