Small nucleolar RNA R41

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Small nucleolar RNA R41
GO
GO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In

small nucleolar RNA
(snoRNA) and also often referred to as a guide RNA.

snoR41 belongs to the

C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

snoR41 was identified by computational screening the rice Oryza sativa genome and is predicted to act as a methylation guide for 18S and 25S ribosomal RNA (rRNA). snoR41 has been alternatively named snoZ154 and snoZ231 in rice. The 18S methylation site is reported to be homologous to that targeted by U62 in humans but there appears to be little sequence similarity between the two snoRNAs.

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