Small nucleolar RNA SNORA65
| Small nucleolar RNA SNORA65 | |
|---|---|
| SO | SO:0000594 |
| PDB structures | PDBe |
In
eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA
(snoRNA) and also often referred to as a 'guide RNA'.
U65 was originally cloned from
H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and has the conserved H/ACA-box motifs.[2]
snoRNA U65 is predicted to guide the pseudouridylation of residues U4373 and U4427 of 28S ribosomal RNA (rRNA).[3]
Pseudouridylation is the isomerisation of the nucleoside uridine to pseudouridine(Ψ). U65 is related to the snoRNA MBII-351 identified in mouse.[4]
References
- PMID 9106664.
- S2CID 8968788.
- ^ Entry for U65 at snoRNABase
- PMID 11387227.
External links
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