Small nucleolar RNA SNORD43
| Small nucleolar RNA SNORD43 | |
|---|---|
| SO | SO:0000593 |
| PDB structures | PDBe |
In
small nucleolar RNA
(snoRNA) and also often referred to as a guide RNA.
snoRNA U43 belongs to the
C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]
U43 is encoded in intron 1 of the ribosomal protein L3 gene in human and cow.[2] Three other snoRNAs ( U82, U83a and U83b) are also encoded in the same host gene but from different introns.[2] The Arabidopsis thaliana homologue is called snoR41 in the public sequence databases (Genbank). The rice homologue is expressed from a cluster also containing snoR16.[3]
U43 is hypothesised to guide methylation of 2'-O-ribose residues on 18S ribosomal RNA.[3]
References
External links
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