Small nucleolar SNORD12/SNORD106
| Small nucleolar SNORD12/SNORD106 | |
|---|---|
| SO | SO:0000593 |
| PDB structures | PDBe |
In
C/D class of small nucleolar RNAs (snoRNAs). Both contain the conserved C (UGAUGA) and D (CUGA) box sequence motifs[1]
Human SNORD12 (HBII-99) is the homologue of mouse snoRNA MBII-99. In humans both HB11-99 and U106 snoRNAs share the same host gene.[2][3]
Most of the members of the box C/D family function in directing site-specific 2'-O-
rRNA.[5] However, these targets do not appear to be methylated and U106 might function as an RNA chaperone during rRNA folding.[2] A similar role has been suggested for the H/ACA snoRNAs U17a and U17b[2]
References
External links
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