Succinate—CoA ligase (ADP-forming)
succinate-CoA ligase (ADP-forming) | |||||||||
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ExPASy NiceZyme view | | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In
enzymology, a succinate-CoA ligase (ADP-forming) (EC 6.2.1.5) is an enzyme that catalyzes the chemical reaction
- ATP + succinate + CoA ADP + phosphate + succinyl-CoA
The 3
.This enzyme belongs to the family of
propanoate metabolism, c5-branched dibasic acid metabolism, and reductive carboxylate cycle
(CO2 fixation).
Structural studies
As of late 2007, 12
structures have been solved for this class of enzymes, with PDB accession codes 1CQI, 1CQJ, 1JKJ, 1JLL, 1OI7, 1SCU, 2NU6, 2NU7, 2NU8, 2NU9, 2NUA, and 2SCU
.
References
- PMID 9917402.
- Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
- Kaufman S (1955). "Studies on the mechanism of the reaction catalyzed by the phosphorylating enzyme". J. Biol. Chem. 216 (1): 153–164. PMID 13252015.
- Kaufman S; Alivasatos SGA (1955). "Purification and properties of the phosphorylating enzyme from spinach". J. Biol. Chem. 216 (1): 141–152. PMID 13252014.