Tanycyte
| Tanycyte | |
|---|---|
 Third ventricle wall in the brain of an immature rat. A tanycyte coexpressing CuZn SOD and GFAP is marked by the arrow. | |
| Details | |
| Location | Ependyma of third ventricle of the brain |
| Identifiers | |
| Latin | tanycytus |
| NeuroLex ID | sao1149261773 |
| TH | H2.00.06.2.01007 |
| FMA | 54560 |
| Anatomical terms of microanatomy | |
Tanycytes are special
The term tanycyte comes from the Greek word tanus which means elongated.
Location
Tanycytes in adult mammals are found in the ventricular system and the circumventricular organs. They are most numerous in the third ventricle of the brain, are also found in the fourth ventricle, and can also be seen in the spinal cord radiating from the ependyma of the central canal to the spinal cord surface. Tanycytes represent approximately 0.6% of the population of the lateral ventricular wall.[1]
Tanycytes have also been shown in vivo to serve as a diet-responsive neurogenic niche.[2]
Function
Recent work suggests that tanycyte cells bridge the gap between the central nervous system (CNS) via cerebrospinal fluid (CSF) to the hypophyseal portal blood.[3][4]
Role in the release of gonadotropin-releasing hormone
Researches in 2005 and 2010[5][6] found that tanycytes participate in the release of gonadotropin-releasing hormone (GnRH). GnRH is released by neurons located in the rostral hypothalamus. These nerve fibers are concentrated in the region that exactly matches the distribution of β1 tanycytes. β1 and β2 tanycytes are found nearer the arcuate nucleus and the median eminence.[7]
See also
List of distinct cell types in the adult human body
References
- Bibliography
- Rodríguez, EM; Blázquez, JL; Pastor, FE; Peláez, B; Peña, P; Peruzzo, B; Amat, P (2005). "Hypothalamic tanycytes: a key component of brain-endocrine interaction" (PDF). International Review of Cytology. 247: 89–164. PMID 16344112.
- Kubota, T; Sato, K; Arishima, H; Takeuchi, H; Kitai, R; Nakagawa, T (Feb 2006). "Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation". Neuropathology. 26 (1): 72–81. S2CID 21225763.
- Guadaño-Ferraz, A; Obregón, MJ; St Germain, DL; Bernal, J (Sep 16, 1997). "The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10391–6. PMID 9294221.
- Prieto, M; Chauvet, N; Alonso, G (Jan 2000). "Tanycytes transplanted into the adult rat spinal cord support the regeneration of lesioned axons". Experimental Neurology. 161 (1): 27–37. S2CID 42078438.
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