Acne fulminans

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Acne fulminans
SpecialtyDermatology Edit this on Wikidata

Acne fulminans (also known as "acute febrile ulcerative acne"[1]: 686 ) is a severe form of the skin disease, acne, which can occur after unsuccessful treatment for another form of acne, acne conglobata. The condition is thought to be an immunologically induced disease in which elevated level of testosterone causes a rise in sebum and population of Cutibacterium acnes bacteria. The increase in the amount of C acnes or related antigens may trigger the immunologic reaction in some individuals and lead to an occurrence of acne fulminans.[2] In addition to testosterone, isotretinoin may also precipitate acne fulminans, possibly related to highly increased levels of C acnes antigens in the patient's immune system.[3] Acne fulminans is a rare disease. Over the past several years, fewer cases of this disease have occurred, possibly because of earlier and better treatment of acne. Approximately 100 patients with acne fulminans have been described.[4]

Signs and symptoms

Acne fulminans begins as pain and inflammation in the joints.[5] It eventually progresses into a swelling of the lymph nodes located at the base of the neck, causing inflexibility in the neck within weeks after the nodes swell. This swelling will eventually decrease, but this decrease will be accompanied by an increased inflammation and swelling of the joints, as well as a complete loss of appetite, though these symptoms are often ignored. After some time, the disease will cause an extreme loss of weight and atrophy of the muscles, leading to the decline of physical abilities.[6]

Outcome and treatment

There is limited evidenced-based data concerning the treatment of AF.

antibiotics.[9] Recurrent AF is extremely rare. Bone lesions typically resolve with treatment, but residual radiographic changes, such as sclerosis and hyperostosis, may remain. Scarring and fibrosis may result from this acute inflammatory process. The disease activates at the height of puberty, usually at around 13 years of age. Acne fulminans predominantly affects young Hispanic White males aged 13 to 22 years with a history of acne. Studies have found successful treatment with Antimicrobial Agents and Oral Prednisolone.[10]

History

In 1958, at a meeting of the Detroit Dermatological Society, Burns and Colville presented a 16-year-old white boy with acute febrile disease and acne conglobata. Many similar cases have been reported since then.[11] Genetic factors may play an important role in some patients; 4 sets of identical twins who developed an identical pattern of acne fulminans have been documented.[12]

See also

  • List of cutaneous conditions

References

  1. ISBN 0-07-138076-0
    .
  2. PMID 2522757
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  3. PMID 16004026
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  4. S2CID 657256
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  5. ^ Zaenglein, Andrea L.; Graber, Emmy M.; Thiboutot, Diane M. (2019), Kang, Sewon; Amagai, Masayuki; Bruckner, Anna L.; Enk, Alexander H. (eds.), "Acne Variants and Acneiform Eruptions", Fitzpatrick's Dermatology (9 ed.), New York, NY: McGraw-Hill Education, retrieved 2022-03-26
  6. PMID 14007467
    .
  7. S2CID 205514693
    .
  8. S2CID 31943912
    .
  9. PMID 15858507
    .
  10. PMID 28428896
    .
  11. ^ Burns RE, Colville JM (1959). "Acne conglobata with septicemia". Arch. Dermatol. 79: 361.
  12. PMID 84495
    .

External links
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