Adrenosterone

Source: Wikipedia, the free encyclopedia.
Adrenosterone
Names
IUPAC name
Androst-4-ene-3,11,17-trione
Systematic IUPAC name
(3aS,3bS,9aR,9bS,11aS)-9a,11a-Dimethyl-2,3,3a,3b,4,5,8,9,9a,9b,11,11a-dodecahydro-1H-cyclopenta[a]phenanthrene-1,7,10-trione
Other names
Reichstein's substance G
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.006.222 Edit this at Wikidata
MeSH Adrenosterone
UNII
  • InChI=1S/C19H24O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-14,17H,3-8,10H2,1-2H3/t13-,14-,17+,18-,19-/m0/s1 checkY
    Key: RZRPTBIGEANTGU-IRIMSJTPSA-N checkY
  • InChI=1/C19H24O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-14,17H,3-8,10H2,1-2H3/t13-,14-,17+,18-,19-/m0/s1
    Key: RZRPTBIGEANTGU-IRIMSJTPBG
  • O=C4/C=C3/CC[C@@H]2[C@H](C(=O)C[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4
Properties
C19H24O3
Molar mass 300.39 g/mol
Melting point 222 °C (432 °F; 495 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Adrenosterone, also known as Reichstein's substance G , as well as 11-ketoandrostenedione (11-KA4), 11-oxoandrostenedione (11-OXO), and androst-4-ene-3,11,17-trione, is a

11-ketotestosterone.[2]

Adrenosterone is sold as a

11βHSD1 inhibitor, which is responsible for activation of cortisol from cortisone.[3]
Thus preventing muscle breakdown, and contributing to a majority of its effects.

See also

References

  1. S2CID 4079662
    .
  2. PMID 19369122
    .
  3. PMID 20355175
    .
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