Lipoidal estradiol
Source: Wikipedia, the free encyclopedia.
Class of chemical compounds
Lipoidal estradiol (LE2) is the variety of
hydrophobic and are found in highest concentrations in adipose tissue and other estrogen-sensitive tissues and in low but detectable concentrations in circulation, with none excreted in urine.[1][2] They have been referred to as the "endogenous counterparts of the synthetic esters of estrogens" like estradiol valerate and estradiol cypionate.[1][2]
Two of the estradiol esters that compose LE2, estradiol palmitate and estradiol stearate, have been developed and marketed for medical use as long-acting estrogens for use via depot intramuscular injection.[3][4]
Estradiol is esterified into LE2 by lecithin–cholesterol acyltransferase (LCAT).[5]
See also
- Catechol estrogen
- Estradiol undecanoate
- Estrogen conjugate
- Steroid sulfate
References
- ^ ISBN 978-3-642-58616-3.
- ^ S2CID 19866729.
- ISBN 978-1-4757-2085-3.
- ISBN 978-3-88763-075-1.
- PMID 15351099.
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SERDs Tooltip selective estrogen receptor downregulators) |
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| Aromatase inhibitors |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
- See also
- Estrogen receptor modulators
- Androgens and antiandrogens
- Progestogens and antiprogestogens
- List of estrogens