Bence Jones protein
Bence Jones protein is a monoclonal
Waldenström's macroglobulinemia.[citation needed
]
Bence Jones proteins are particularly diagnostic of multiple myeloma in the context of target organ manifestations such as kidney failure, lytic (or "punched out") bone lesions, anemia, or large numbers of plasma cells in the bone marrow. Bence Jones proteins are present in 2/3 of multiple myeloma cases.[3]
The proteins are
serum free light chain assays have been utilised in a number of published studies which have indicated superiority over the urine tests, particularly for patients producing low levels of monoclonal free light chains, as seen in nonsecretory multiple myeloma[5][6][7] and amyloid light chain amyloidosis (AL amyloidosis).[7][8][9][10]
History
The Bence Jones protein was described by the English physician Henry Bence Jones in 1847 and published in 1848.[11]
References
- ^ Bernier, G. M. & Putnam, F. W. (1963). Nature (London), 200, 223±225.
- ^ Anderson, Alyssa. "What Is a Bence-Jones Protein Test?". WebMD. Retrieved 27 September 2023.
- ^ ISBN 978-1-4051-3649-5.
- ^ "Bence Jones Protein Test". TheFreeDictionary.com.
- S2CID 8779162.
- PMID 16879026.
- ^ PMID 15774572.
- S2CID 23475887.
- PMID 12579999.
- S2CID 7839338.
- S2CID 186208792.