CatSper1
Appearance
CATSPER1 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 11: 66.02 – 66.03 Mb | Chr 19: 5.39 – 5.39 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
CatSper1, is a
Ca2+-permeant ion channel specific essential for the correct function of sperm cells.[8]
Function
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to
spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000175294 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038498 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11675491.
- S2CID 4424815.
- S2CID 35096827.
- ^ "CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-05. Retrieved 2008-12-16.
- ^ "Entrez Gene: CatSper1".
Further reading
- Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa". Asian J. Androl. 8 (3): 301–6. PMID 16625279.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. S2CID 4427026.
- Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. PMID 16740636.
- Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein". Am. J. Hum. Genet. 84 (4): 505–10. PMID 19344877.
- Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. S2CID 6099942.
- Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. PMID 11675491.
- Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. S2CID 35096827.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility". Hum. Reprod. 19 (1): 124–8. PMID 14688170.
- Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. S2CID 4424815.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.