CLCA1
| CLCA1 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 1: 86.47 – 86.5 Mb | Chr 3: 144.71 – 144.74 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[5][6]
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.metalloprotease.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000016490 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028255 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9828122.
- ^ a b "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1".
- S2CID 40041491.
Further reading
- Hume JR, Duan D, Collier ML, et al. (2000). "Anion transport in heart". Physiol. Rev. 80 (1): 31–81. S2CID 15954128.
- Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. S2CID 28762005.
- Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. S2CID 82094058.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
- Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. PMID 10758170.
- Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. PMID 11842292.
- Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. PMID 11994272.
- Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. PMID 12110680.
- Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. PMID 12408984.
- Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–65, discussion 165–70, 277–82. PMID 12568493.
- Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. PMID 14512419.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Hegab AE, Sakamoto T, Uchida Y, et al. (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. 41 (3): 27e–27. PMID 14985398.
- Kamada F, Suzuki Y, Shao C, et al. (2005). "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. 5 (7): 540–7. PMID 15318163.
- Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. S2CID 12935280.
- Gibson A, Lewis AP, Affleck K, et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. PMID 15919655.
- Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. PMID 16023076.
External links
- CLCA1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCA1 genome location and CLCA1 gene details page in the UCSC Genome Browser.
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