CLIC6
| CLIC6 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 21: 34.67 – 34.72 Mb | Chr 16: 92.28 – 92.34 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Chloride intracellular channel protein 6 is a protein that in humans is encoded by the CLIC6 gene.[5][6]
The CLIC6 gene encodes a member of the
chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.[6]
Interactions
CLIC6 has been shown to
interact with Dopamine receptor D3.[7]
Function
CLIC6 has been shown to form
ion channels. It is predominantly expressed in the plasma membrane of lung epithelial cells. [8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000159212 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022949 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 10830953.
- ^ a b "Entrez Gene: CLIC6 chloride intracellular channel 6".
- PMID 14499480.
- PMID 37838179.
Further reading
- Singh H (May 2010). "Two decades with dimorphic Chloride Intracellular Channels (CLICs)". FEBS Letters. 584 (10): 2112–2121. S2CID 21056278.
- Strippoli P, D'Addabbo P, Lenzi L, Giannone S, Canaider S, Casadei R, et al. (August 2002). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q". Mammalian Genome. 13 (8): 456–462. S2CID 26059147.
- Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, et al. (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
- Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P (September 2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Research. Molecular Brain Research. 117 (1): 47–57. PMID 14499480.
- Friedli M, Guipponi M, Bertrand S, Bertrand D, Neerman-Arbez M, Scott HS, et al. (November 2003). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12". Gene. 320: 31–40. PMID 14597386.
External links
- CLIC6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CLIC6 genome location and CLIC6 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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