Grieco elimination
The Grieco elimination is an organic reaction describing the elimination reaction of an aliphatic primary alcohol through a selenide to a terminal alkene.[1][2] It is named for Paul Grieco.
The alcohol first reacts with o-nitrophenylselenocyanate and
Cope elimination. This reaction takes part in the synthesis of ring C of the Danishefsky Taxol synthesis
.
The elimination step is common with the Clive-Reich-Sharpless olefination that uses PhSeX as the selenium source.[3]
References
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- ISBN 9780080966311.