Melengestrol acetate

Source: Wikipedia, the free encyclopedia.
Not to be confused with Megestrol acetate.
Melengestrol acetate
Progestin; Progestogen ester
ATC code
  • None
Identifiers
  • [(8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-16-methylidene-3-oxo-1,2,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthren-17-yl] acetate
JSmol)
  • O=C4\C=C3\C(=C/[C@@H]1[C@H](CC[C@@]2([C@](OC(=O)C)(C(=C)\C[C@@H]12)C(=O)C)C)[C@@]3(C)CC4)C
  • InChI=1S/C25H32O4/c1-14-11-19-20(23(5)9-7-18(28)13-21(14)23)8-10-24(6)22(19)12-15(2)25(24,16(3)26)29-17(4)27/h11,13,19-20,22H,2,7-10,12H2,1,3-6H3/t19-,20+,22+,23-,24+,25+/m1/s1
  • Key:UDKABVSQKJNZBH-DWNQPYOZSA-N

Melengestrol acetate (MLGA), sold under the brand names Heifermax and MGA among others, is a

contraceptive for captive animals in zoos and other refuges,[3] and is also used as a feed additive to promote growth in cattle, a purpose it is licensed for in the United States and Canada.[4]

Uses

Animal reproduction

MLGA is used in

animal reproduction.[3][4]

Pharmacology

Pharmacodynamics

MLGA is a

rhesus monkey uterus.[5]

Chemistry

See also: List of progestogens, Progestogen ester, and List of progestogen esters

MLGA, also known as 17α-acetoxy-16-methylene-6-dehydro-6-methylprogesterone or as 17α-acetoxy-16-methylene-6-methylpregna-4,6-diene-3,20-dione, is a

Analogues of MLGA include other 17α-hydroxyprogesterone derivatives such as chlormadinone acetate, chlormethenmadinone acetate, cyproterone acetate, delmadinone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, megestrol acetate, methenmadinone acetate, and osaterone acetate.[1] The only structural difference between MLGA and megestrol acetate is the presence of the C16 methylene group in the former.[1]

Society and culture

Generic names

Melengestrol acetate is the

INNTooltip International Nonproprietary Name and BANTooltip British Approved Name of the unesterified free alcohol form.[1][2]

Brand names

MLGA is marketed under the brand names Heifermax and MGA among others.[1][2]

References

  1. ^
    ISBN 978-1-4757-2085-3
    .
  2. ^ a b c d e f "Melengestrol". Drugs.com. Archived from the original on 30 July 2017.
  3. ^
    ISBN 9780226440118
    . Retrieved 17 March 2016.
  4. ^
    ISBN 978-0-85404-198-5
    . Retrieved 27 May 2012.
  5. ^
    PMID 405534
    .
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