Ethylestrenol
Clinical data | |
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Trade names | Maxibolin, Orabolin, others |
Other names | Ethyloestrenol; Ethylnandrol; ORG-483; 3-Deketo-17α-ethyl-19-nortestosterone; 17α-Ethylestr-4-en-17β-ol; 19-Nor-17α-pregn-4-en-17β-ol |
AHFS/Drugs.com | International Drug Names |
Routes of administration | By mouth |
Drug class | Androgen; Anabolic steroid; Progestogen |
ATC code | |
Legal status | |
Legal status |
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Identifiers | |
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Ethylestrenol, also known as ethyloestrenol or ethylnandrol and sold under the brand names Maxibolin and Orabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used in the past for a variety of indications such as to promote weight gain and to treat anemia and osteoporosis but has been discontinued for use in humans.[2] It is still available for veterinary use in Australia and New Zealand however.[3] It is taken by mouth.[2]
Ethylestrenol was first described in 1959 and was introduced for medical use in 1961.[5][2][6] In addition to its medical use, ethylestrenol has been used to improve physique and performance.[2] However, it is described as a very weak muscle-builder compared to other AAS and in relation to this has not been commonly used for such purposes.[2] The drug is a controlled substance in many countries and so non-medical use is generally illicit.[2]
Medical uses
Ethylestrenol has been used for a variety of indications including:[2]
- To promote muscle growth[7]
- As an
- As an adjunct for
- To treat treatment-refractory anemias (via stimulation of erythropoiesis) such as acquired and congenital aplastic anemia and anemia of chronic kidney disease[7][8]
- As an adjunct to improve strength and well-being in arthritis[8]
- To treat short stature in youth[9]
Contraindications
Ethylestrenol should not be taken by
Side effects
Side effects of ethylestrenol include virilization among others.[2]
Pharmacology
Pharmacodynamics
Medication | Ratioa |
---|---|
Testosterone | ~1:1 |
Androstanolone (DHT) | ~1:1 |
Methyltestosterone | ~1:1 |
Methandriol | ~1:1 |
Fluoxymesterone | 1:1–1:15 |
Metandienone | 1:1–1:8 |
Drostanolone | 1:3–1:4 |
Metenolone | 1:2–1:30 |
Oxymetholone | 1:2–1:9 |
Oxandrolone | 1:3–1:13 |
Stanozolol | 1:1–1:30 |
Nandrolone | 1:3–1:16 |
Ethylestrenol | 1:2–1:19 |
Norethandrolone | 1:1–1:20 |
Notes: In rodents. Footnotes: a = Ratio of androgenic to anabolic activity. Sources: See template. |
As an AAS, ethylestrenol is an
Compound | rAR (%) | hAR (%) | ||||||
---|---|---|---|---|---|---|---|---|
Testosterone | 38 | 38 | ||||||
5α-Dihydrotestosterone | 77 | 100 | ||||||
Nandrolone | 75 | 92 | ||||||
5α-Dihydronandrolone | 35 | 50 | ||||||
Ethylestrenol | ND | 2 | ||||||
Norethandrolone | ND | 22 | ||||||
5α-Dihydronorethandrolone | ND | 14 | ||||||
Metribolone | 100 | 110 | ||||||
Sources: See template. |
Pharmacokinetics
Ethylestrenol has very low
Chemistry
Ethylestrenol, also known as 3-deketo-17α-ethyl-19-nortestosterone or as 17α-ethylestr-4-en-17β-ol, is a
History
Ethylestrenol was described in the literature in 1959 and approved for medical use in 1961 and in the United States in 1964.[5][2][6]
Society and culture
Generic names
Ethylestrenol is the
Brand names
Ethylestrenol is or has been marketed under a variety of brand names including Durabolin O, Duraboral, Fertabolin, Maxibolin, Maxibolin Elixir, Orabolin, Orgabolin, Orgaboral, and Virastine.
Availability
The availability of ethylestrenol is very limited.[2][12][3] It appears to be available only in Australia and New Zealand and in these countries only for veterinary use.[2][3]
Legal status
Ethylestrenol, along with other AAS, is a
References
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
- ^ ISBN 978-0-9828280-1-4.
- ^ a b c d e f "Ethylestrenol". Drugs.com. Archived from the original on 2017-11-11. Retrieved 2017-11-10.
- ^ PMID 18500378.
- ^ ISBN 978-1-4757-2085-3.
- ^ ISBN 978-0-8155-1856-3.
- ^ ISBN 978-1-4200-4744-8.
- ^ ISBN 978-1-4684-5499-4.
- ^ ISBN 978-0-313-31807-8.
- PMID 6539197.
- PMID 3865479.
- ^ ISBN 978-3-88763-075-1.
- ^ ISBN 978-94-011-4439-1.
- ISBN 978-1-4200-0346-8.