Proligestone

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Proligestone
Progestin
ATC code
)
Identifiers
  • 14α,17α-(propylidenebis(oxy))pregn-4-ene-3,20-dione
JSmol)
SMILES
  • CCC1O[C@@]23CC[C@]([C@]2(CC[C@H]4[C@H]3CCC5=CC(=O)CC[C@]45C)C)(O1)C(=O)C
  • InChI=1S/C24H34O4/c1-5-20-27-23(15(2)25)12-13-24(28-20)19-7-6-16-14-17(26)8-10-21(16,3)18(19)9-11-22(23,24)4/h14,18-20H,5-13H2,1-4H3/t18-,19+,20?,21-,22+,23-,24+/m0/s1
  • Key:MQSDUYIXZDSLSZ-QSDCUGRSSA-N

Proligestone, sold under the brand names Covinan and Delvosteron, is a

progestin medication which is used in veterinary medicine.[1][2][3]

Uses

Veterinary

Proligestone is used to control

estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats.[4]

Pharmacology

Pharmacodynamics

Proligestone is a progestogen, or an agonist of the progesterone receptor (PR).

Chemistry

See also: List of progestogens and List of progestogen esters § Cyclic ketals of progesterone derivatives

Proligestone, also known as 14α,17α-propylidenedioxyprogesterone or as 14α,17α-dihydroxyprogesterone cyclic acetal with propionaldehyde, as well as 14α,17α-propylidenedioxypregn-4-ene-3,20-dione, is a

ketal of 14α,17α-dihydroxyprogesterone.[5][6][7]

History

Proligestone was described as early as 1968 and was introduced for veterinary use in 1975.[1][8][9]

Society and culture

Generic names

Proligestone is the

INNTooltip International Nonproprietary Name and BANTooltip British Approved Name.[1][2][3]

Brand names

Proligestone is marketed under the brand names Covinan and Delvosteron.[1][2][3]

Availability

Proligestone is or has been available for veterinary use in Argentina, Australia, Austria, Belgium, Czechoslovakia, France, Germany, Ireland, Italy, the Netherlands, New Zealand, Poland, South Africa, Switzerland, and the United Kingdom.[2][3]

References

  1. ^
    ISBN 978-1-4757-2085-3
    .
  2. ^
    ISBN 978-3-88763-075-1
    .
  3. ^ a b c d "List of Progestins". Drugs.com.
  4. ^ Mundt S (22 April 1981). "Indications for proligestone (Delvosteron) in dogs and cats". Praktische Tierarzt. 62 (12).
  5. ISBN 978-90-219-0298-2
    .
  6. ISBN 978-3-527-30247-5
    .
  7. ^ "Proligestone". Medical Subject Headings: Supplementary chemical records. U.S. National Library of Medicine.
  8. ^ Official Gazette of the United States Patent and Trademark Office: Trademarks. U.S. Department of Commerce, Patent and Trademark Office. 1984. p. 30.
  9. PMID 567718
    .
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