Meropenem/vaborbactam
Combination of | |
---|---|
β-lactam antibiotic | |
Vaborbactam | β-lactamase inhibitor |
Clinical data | |
Trade names | Vabomere, Vaborem, others |
AHFS/Drugs.com | Monograph |
License data | |
Intravenous | |
ATC code | |
Legal status | |
Legal status |
|
Identifiers | |
CAS Number | |
KEGG |
Meropenem/vaborbactam, sold under the brand name Vabomere among others, is a
Common side effects include headache, inflammation at the site of injection, nausea, diarrhea, liver inflammation, and
The combination was approved for medical use in the United States in 2017 and Europe in 2018.[1][2] It is on the World Health Organization's List of Essential Medicines.[4]
Antimicrobial activity
Meropenem/vaborbactam retains antimicrobial activity against class A and class C β-lactamase-producing Enterobacterales, especially those producing
Medical uses
It is used to treat complicated
In a study of 545 adults with complicated urinary tract infections, 98 percent of adults treated with Vabomere compared with about 94 percent of adults treated with piperacillin/tazobactam were cured defined as improvement in symptoms and a negative urine culture. About seven days after completing treatment, roughly 77 percent of adults treated with Vabomere compared with about 73 percent of those treated with piperacillin/tazobactam had resolved symptoms and a negative urine culture.[6]
Children
Successful bacteremia clearance in a child has been reported using a meropenem-vaborbactam dose of 40 mg/kg every 6 hours given over 3 hours. It attained 100% of meropenem serum concentrations above the minimum inhibitory concentration for at least 40% of the dosing interval.[7]
Side effects
The most common adverse reactions were headache, infusion site reactions and diarrhea. Serious risks include allergic reactions and seizures and Meropenem/vaborbactam should not be used in people with severe allergic reactions to penicillins.[6]
History
Rempex Pharmaceuticals developed the drug. It was designated as a "qualified infectious disease product" under the Generating Antibiotic Incentives Now (GAIN) title of the FDA Safety and Innovation Act and therefore received priority review. [citation needed]
In August 2017, the US Food and Drug Administration approved it to treat complicated urinary tract infections and pyelonephritis.[6]
References
- ^ a b c d e f g h "Vabomere (combination) Monograph for Professionals". Drugs.com. Retrieved 6 November 2019.
- ^ a b c "Vaborem". European Medicines Agency. 24 September 2018. Retrieved 6 November 2019.
- ^ "Meropenem / vaborbactam (Vabomere) Use During Pregnancy". Drugs.com. Retrieved 6 November 2019.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- PMID 35455461.
- ^ a b c "FDA approves new antibacterial drug" (Press release). Food and Drug Administration (FDA). 29 August 2017.
This article incorporates text from this source, which is in the public domain.
- S2CID 52948188.
External links
- "Meropenem mixture with vaborbactam". Drug Information Portal. U.S. National Library of Medicine.