Cefacetrile

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Cefacetrile
QJ51DB10 (WHO)
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding23 to 38%
Elimination half-life1.2 hours
ExcretionRenal (72%)
Identifiers
  • (6R,7R)-3-(acetyloxymethyl)-7-[(2-cyanoacetyl)amino]-
    8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-
    carboxylic acid
JSmol)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)CC#N)COC(=O)C)C(=O)O
  • InChI=1S/C13H13N3O6S/c1-6(17)22-4-7-5-23-12-9(15-8(18)2-3-14)11(19)16(12)10(7)13(20)21/h9,12H,2,4-5H2,1H3,(H,15,18)(H,20,21)/t9-,12-/m1/s1 checkY
  • Key:RRYMAQUWDLIUPV-BXKDBHETSA-N checkY
  (verify)

Cefacetrile (

mammary infections in lactating cows.[2]

Synthesis

Ciba-Geigy
).

It was made by reacting 7-ACA (7-aminocephalosporanic acid) with cyanoacetyl chloride in the presence of tributylamine.[citation needed]

References

  1. ^ "Cefacetrile Summary Report" (PDF). European Medicines Agency, Committee for Veterinary Medicinal Products. 1998. Archived from the original (PDF) on 2020-05-26. Retrieved 2012-01-25.
  2. ^
    ISBN 978-3-85200-183-8
    .
  3. PMID 7206219
    .
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