Carbenicillin
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Clinical data | |
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Trade names | Geocillin; Pyopen |
Other names | CB[1] |
AHFS/Drugs.com | Monograph |
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Routes of administration | Oral, parenteral |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | 30 to 40% |
Protein binding | 30 to 60% |
Metabolism | Minimal |
Elimination half-life | 1 hour |
Excretion | Renal (30 to 40%) |
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Carbenicillin is a
Pharmacology
The antibiotic is highly soluble in water and is acid-labile. A typical lab working concentration is 50 to 100 μg per mL.[citation needed]
It is a semi-synthetic analogue of the naturally occurring benzylpenicillin. Carbenicillin at high doses can cause bleeding. Use of carbenicillin can cause hypokalemia by promoting potassium loss at the distal convoluted tubule of the kidney.[citation needed]
In
Spectrum of bacterial susceptibility and resistance
Carbenicillin has been shown to be effective against bacteria responsible for causing urinary tract infections including Pseudomonas aeruginosa, Escherichia coli, and some Proteus species. The following represents carbenicillin susceptibility data for a few medically significant organisms.[3] This is not representative of all species of bacteria susceptible to carbenicillin exposure.
- Escherichia coli 1.56 μg/ml - 64 μg/ml
- Proteus mirabilis 1.56 μg/ml - 3.13 μg/ml
- Pseudomonas aeruginosa 3.13 μg/ml - >1024 μg/ml
References
- ^ "Antibiotic abbreviations list". Retrieved 22 June 2023.
- PMID 21771.
- ^ "Carbenicillin Disodium, USP Susceptibility and Minimum Inhibitory Concentration (MIC) Data" (PDF). January 6, 2020.
Further reading
- Pawełczyk E, Zajac M, Knitter B, Mikołajczak P (October 1981). "Kinetics of drug decomposition. Part 66. Kinetics of the hydrolysis of carphecillin in aqueous solution". Polish Journal of Pharmacology and Pharmacy. 33 (3): 373–86. PMID 7322950.