Procaine benzylpenicillin

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Procaine benzylpenicillin
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Procaine benzylpenicillin also known as penicillin G procaine, is an

injection into a muscle.[2]

Side effects include pain at the site of injection,

beta lactam family of medications.[2] It works via benzylpenicillin and results in bacterial death.[2][3] Procaine makes the combination long acting.[4]

Procaine benzylpenicillin was introduced for medical use in 1948.[3] It is on the World Health Organization's List of Essential Medicines.[5]

Medical uses

Specific indications for procaine penicillin include:[6]

  • Syphilis
    • In the United States, Bicillin C-R (an injectable suspension which 1.2 million units of benzathine penicillin and 1.2 million units of procaine penicillin per 4 ml) is not recommended for treating syphilis, since it contains only half the recommended dose of benzathine penicillin. Medication errors have been made due to the confusion between Bicillin L-A & Bicillin C-R.[7] As a result, changes in product packaging have been made; specifically, the statement "Not for the Treatment of Syphilis" has been added in red text to both the Bicillin CR and Billin CR 900/300 syringe labels.[8]
  • Respiratory tract infections where compliance with oral treatment is unlikely
  • Alongside Pen V and Erythromycin, Bicillin C-R is used to treat
    strep throat
    , given as one IM injection
  • Cellulitis, erysipelas
  • Procaine penicillin is also used as an adjunct in the treatment of anthrax.

Adverse effects

Further information:
Penicillin drug reaction

At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present in it.[citation needed]

Mechanism

It is a form of

intramuscular injection, it is slowly absorbed into the circulation and hydrolysed
to benzylpenicillin — thus it is used where prolonged low concentrations of benzylpenicillin are required.

Compendial status

See also

References

  1. ^
    ISBN 9781284057560
    .
  2. ^
    ISBN 9789241547659
    .
  3. ^ a b "Penicillin G Procaine - FDA prescribing information, side effects and uses". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
  4. ISBN 9781420047448. Archived
    from the original on 2016-12-20.
  5. hdl:10665/325771
    . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  6. ISBN 0-9757919-2-3
    .
  7. PMID 15758893
    .
  8. ^ United States Food & Drug Administration. "FDA Strengthens Labels of Two Specific Types of Antibiotics to Ensure Proper Use." Archived 2009-01-14 at the Wayback Machine Published December 1, 2004. Last accessed June 18, 2007.
  9. ISBN 9789251042809
    .
  10. ^ British Pharmacopoeia Commission Secretariat. "Index (BP 2009)" (PDF). Archived from the original (PDF) on 11 April 2009. Retrieved 26 March 2010.

External links

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