Cefapirin

Cefapirin
	QJ51DB08 (WHO)
Legal status
Legal status	US: ℞-only;
Identifiers
JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)CSc3ccncc3)COC(=O)C)C(=O)O;
	InChI InChI=1S/C17H17N3O6S2/c1-9(21)26-6-10-7-28-16-13(15(23)20(16)14(10)17(24)25)19-12(22)8-27-11-2-4-18-5-3-11/h2-5,13,16H,6-8H2,1H3,(H,19,22)(H,24,25)/t13-,16-/m1/s1 ; Key:UQLLWWBDSUHNEB-CZUORRHYSA-N ;
	(verify)

Cefapirin (

INN, also spelled cephapirin) is an injectable, first-generation cephalosporin antibiotic. It is marketed under the trade name Cefadyl. Production for use in humans has been discontinued in the United States.^[1]

It also has a role in veterinary medicine as Metricure, an intrauterine preparation, and combined with prednisolone in Mastiplan, an intramammary preparation. Both are licensed in cattle.^{[citation needed]}

Synthesis

In one of the syntheses,

7-aminocephalosporanic acid (7-ACA) is reacted with bromoacetyl chloride to give the amide. The halo group is then displaced by 4-thiopyridine.^[2]

References

^ "CEFADYL". U.S. Food and Drug Administration.
^
PMID 4148798
.

This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it.

[1] "CEFADYL". U.S. Food and Drug Administration.

[Crast-2] 
PMID 4148798
.

[1]

[2]