miR-218 microRNA precursor family
| mir-218 microRNA precursor family | |
|---|---|
| SO | SO:0001244 |
| PDB structures | PDBe |
miR-218 microRNA precursor is a small
miR-218 appears to be a
miR-218 is specifically expressed by mammalian motor neurons during embryonic development into adulthood, and motor neurons lacking expression of miR-218 exhibit hyperexcitability, neuromuscular junction failure, and neurodegeneration, as demonstrated by knockout mouse models.[2]
The involvement of miR-218 in cancer has also been investigated. miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma.[3] It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth.[4] miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.[5] miR-218 expression was associated with overall survival in breast cancer datasets.[6]
References
- ^ "miRNA gene family: mir-218". mirBASE. The University of Manchester. Archived from the original on 2007-09-29.
- PMID 26680198.
- PMID 21795477.
- PMID 21385904.
- PMID 21519788.
- PMID 27744485.
External links