Monocarboxylate transporter 2
| SLC16A7 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 12: 59.6 – 59.79 Mb | Chr 10: 125.06 – 125.23 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a
pyruvate transporter
.
Both Northern blot analysis and inspection of the human
MCT4
and there also appear to be considerable species differences in the tissue expression profile of this isoform.
Of the four known mammalian lactate transporters (MCTs 1-4), MCT2 harbors the highest affinity for lactate.[6] In parallel, MCT2 gene transcription has been demonstrated to respond with high-sensitivity to hypoxia, intracellular pH, and, to lactate.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000118596 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020102 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 22137883.
- S2CID 24460891.
- PMID 28092823.
Further reading
- Pértega-Gomes N, Vizcaíno JR, Gouveia C, Jerónimo C, Henrique RM, Lopes C, Baltazar F (2013). "Monocarboxylate transporter 2 (MCT2) as putative biomarker in prostate cancer". Prostate. 73 (7): 763–9. S2CID 5816396.
- Lee I, Lee SJ, Kang WK, Park C (2012). "Inhibition of monocarboxylate transporter 2 induces senescence-associated mitochondrial dysfunction and suppresses progression of colorectal malignancies in vivo". Mol. Cancer Ther. 11 (11): 2342–51. PMID 22964484.
- Cheng C, Edin NF, Lauritzen KH, Aspmodal I, Christoffersen S, Jian L, Rasmussen LJ, Pettersen EO, Xiaoqun G, Bergersen LH (2012). "Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells". Cell Oncol (Dordr). 35 (3): 217–27. PMID 22700320.
- Lauritzen F, Heuser K, de Lanerolle NC, Lee TS, Spencer DD, Kim JH, Gjedde A, Eid T, Bergersen LH (2012). "Redistribution of monocarboxylate transporter 2 on the surface of astrocytes in the human epileptogenic hippocampus". Glia. 60 (7): 1172–81. PMID 22535546.
- Halestrap AP (2012). "The monocarboxylate transporter family--Structure and functional characterization". IUBMB Life. 64 (1): 1–9. S2CID 24460891.
 | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |