Monocarboxylate transporter 4
| SLC16A3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
| View/Edit Human | View/Edit Mouse |
Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.[5][6]
pyruvate may be especially significant as this avoids loss of pyruvate from the cell which, were it to occur, would prevent removal of the reduced form of nicotinamide adenine dinucleotide
(NADH) produced in glycolysis by reduction of pyruvate to lactate.
MCT4 can be upregulated by HIF-1α and AMPK.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000141526 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025161 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9425115.
- ^ "Entrez Gene: SLC16A3 solute carrier family 16, member 3 (monocarboxylic acid transporter 4)".
- PMID 32144120.
Further reading
- Halestrap AP, Price NT (Oct 1999). "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation". The Biochemical Journal. 343 (2): 281–99. PMID 10510291.
- Halestrap AP, Meredith D (Feb 2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Archiv: European Journal of Physiology. 447 (5): 619–28. S2CID 15498611.
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP (Aug 2000). "CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression". The EMBO Journal. 19 (15): 3896–904. PMID 10921872.
- Philp NJ, Wang D, Yoon H, Hjelmeland LM (Apr 2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Investigative Ophthalmology & Visual Science. 44 (4): 1716–21. PMID 12657613.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Wang Q, Morris ME (Aug 2007). "The role of monocarboxylate transporter 2 and 4 in the transport of S2CID 11072905.
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