SLC26A6
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| Location (UCSC) | Chr 3: 48.63 – 48.64 Mb | Chr 9: 108.73 – 108.74 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]
This gene belongs to the
isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]
Associated diseases
Diseases associated with SLC26A6 include
urolithiasis.[9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11087667.
- PMID 11247665.
- ^ a b "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
- S2CID 23214608.
- ^ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.
Further reading
- Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. S2CID 30942862.
- Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. PMID 10610771.
- Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. PMID 12217875.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMID 15489334.
- Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. PMID 15548529.
- Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. S2CID 26671784.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. PMID 16344560.
- Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. PMID 16606687.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. S2CID 7827573.
- Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. PMID 17120764.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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