Vesicular acetylcholine transporter
| SLC18A3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 10: 49.61 – 49.61 Mb | Chr 14: 32.18 – 32.19 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
The Vesicular acetylcholine transporter (VAChT) is a
vacuolar ATPase
.
VAChT uptake inhibitors
Radiolabeled compounds
PET imaging of the VAChT may provide insights into early diagnosis of Alzheimer's disease.
- (−)-trans-2-Hydroxy-3-(4-(4-[18F]fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000187714 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100241 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 15305436.
- PMID 8622973.
- ^ Waymire J. "Storage of ACh". University of Texas Medical Center.
- PMID 19203271.
Further reading
- Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H (Feb 2011). "Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter". The Journal of Biological Chemistry. 286 (7): 5836–45. PMID 21163949.
- Lau JK, Brown KC, Thornhill BA, Crabtree CM, Dom AM, Witte TR, Hardman WE, McNees CA, Stover CA, Carpenter AB, Luo H, Chen YC, Shiflett BS, Dasgupta P (Feb 2013). "Inhibition of cholinergic signaling causes apoptosis in human bronchioalveolar carcinoma". Cancer Research. 73 (4): 1328–39. PMID 23222296.
- Varoqui H, Erickson JD (Nov 1996). "Active transport of acetylcholine by the human vesicular acetylcholine transporter". The Journal of Biological Chemistry. 271 (44): 27229–32. PMID 8910293.
- Harold D, Peirce T, Moskvina V, Myers A, Jones S, Hollingworth P, Moore P, Lovestone S, Powell J, Foy C, Archer N, Walter S, Edmonson A, McIlroy S, Craig D, Passmore PA, Goate A, Hardy J, O'Donovan M, Williams J, Liddell M, Owen MJ, Jones L (Aug 2003). "Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease". Human Genetics. 113 (3): 258–67. S2CID 24977017.
- Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J (Sep 2007). "Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease". American Journal of Medical Genetics Part B. 144B (6): 762–70. S2CID 26081707.
- Schütz B, Chen L, Schäfer MK, Weihe E, Eiden LE (2000). "Somatomotor neuron-specific expression of the human cholinergic gene locus in transgenic mice". Neuroscience. 96 (4): 707–22. S2CID 44276305.
- Khare P, Mulakaluri A, Parsons SM (Nov 2010). "Search for the acetylcholine and vesamicol binding sites in vesicular acetylcholine transporter: the region around the lumenal end of the transport channel". Journal of Neurochemistry. 115 (4): 984–93. PMID 20831599.
- Tayebati SK, El-Assouad D, Ricci A, Amenta F (Nov 2002). "Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes". Journal of Neuroimmunology. 132 (1–2): 147–55. S2CID 20921312.
- Chireux MA, Le Van Thai A, Weber MJ (Mar 1995). "Human choline acetyltransferase gene: localization of alternative first exons". Journal of Neuroscience Research. 40 (4): 427–38. S2CID 42856768.
External links
- Vesicular+Acetylcholine+Transporter at the U.S. National Library of Medicine Medical Subject Headings (MeSH)