Urea transporter
| UT | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | UT | ||||||||
TCDB | 1.A.28 | ||||||||
| OPM superfamily | 13 | ||||||||
| OPM protein | 3k3f | ||||||||
| |||||||||
A urea transporter is a
The structure of a urea transport family protein from
Urea transporters can be inhibited by the action of urea analogues like thiourea and glycosides like phloretin.[4] Their inhibition results in increased diuresis due to urea induced osmosis in the collecting ducts of the kidney.[5]
Types
In mammals, there are two urea transporter
UT-A1
Urea transporter A1 transports urea across the
UT-A2
Urea Transporter 2 transports urea across the
UT-A3
Urea transporter 3 transports urea into the interstitium of the Inner Medullary Collecting Duct.[6]
UT-A4
Urea transporter 4 has been detected in rat but not mouse kidney medulla.[6]
UT-A5
Urea transporter 5 is not expressed in the kidney but in the testis.[6]
UT-B
UT-B is widely expressed and has been studied in