Heterodimeric amino-acid transporter

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Heterodimeric amino-acid transporters are a family of transport proteins that facilitate the transport of certain amino acids across cell membranes.[1] Each comprises a light and a heavy protein subunit. Transport activity happens in the light.

The following table lists the members of this family:

Transport system Light subunit Heavy subunit Tissue distribution Substrates Affinity Sodium dependence Disease linkage
L LAT1 (
SLC7A5
) 		4F2hc (
SLC3A2
) 		kidney, liver, intestine, brain, heart lung, blood–brain barrier large neutral amino acids,
thyroid hormones
 micromolar no –
L LAT2 (
SLC7A8
) 		4F2hc (SLC3A2) kidney, intestine, brain, liver, muscle, heart, lung smaller neutral amino acids millimolar no –
y+L y+LAT1 (
SLC7A7
) 		4F2hc (SLC3A2) kidney, intestine, lung, erythrocytes, leukocytes large neutral amino acids, dibasic amino acid exchange micromolar yes Lysinuric protein intolerance
y+L y+LAT2 (
SLC7A6
) 		4F2hc (SLC3A2) brain, intestine, heart, kidney, lung, liver neutral amino acids, dibasic amino acid exchange, glutamine/arginine exchange millimolar yes –
xc− xCT (
SLC7A11
) 		4F2hc (SLC3A2) macrophages, liver, kidney, brain glutamine/cystine exchange no –
asc ascAT1 (
SLC7A10
) 		4F2hc (SLC3A2) brain, lung, small intestine, kidney small neutral amino acids no –
b0,+ b0,+AT1 (
SLC7A9
) 		rBAT (
SLC3A1
) 		kidney, intestine, brain neutral/dibasic amino acids no Cystinuria type I

References

  1. S2CID 23112134
    .


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