Monocarboxylate transporter 3
| SLC16A8 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 22: 38.08 – 38.08 Mb | Chr 15: 79.14 – 79.14 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.
Expression of SLC16A8 is confined to the
MCT1
which is found on the apical membrane.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100156 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032988 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 22137883.
Further reading
- Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics. 60 (3): 366–70. PMID 10493836.
- Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. PMID 12657613.
- Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. PMID 15917240.
- Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 18: 377–87. PMID 7273846.
- Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. S2CID 15498611.
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