Chloride potassium symporter

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The chloride potassium

electrochemical equilibrium potential.[2]

The concentrations of K+ and Cl ions are high inside the cell due to the activities of

NKCC cotransporter
, respectively. Hence, their net driving force acting on the K/Cl cotransporter favours the exit of both K+ and Cl from the cell.

Types

Chloride potassium symporter are classified into:

Each is encoded by a separate gene of the solute carrier family 12, hence accounting for the numbers succeeding its name. For example, chloride potassium symporter 5, or KCC2, is expressed through the SLC12A5 gene. Notably, symporters prior to 4 in the same family are other types of ion pumps. SLC12A3, for instance, is the sodium-chloride symporter.

References