GLUT5
| SLC2A5 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process |
| ||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 1: 9.04 – 9.09 Mb | Chr 4: 150.2 – 150.23 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
GLUT5 is a
intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,[6] testis, kidney, fat tissue (adipocytes), and brain.[7]
Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.[8]
In humans the GLUT5 protein is encoded by the SLC2A5 gene.[9]
Regulation
Fructose uptake rate by GLUT5 is significantly reduced by
diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.[10][11][12] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.[13] Fructose absorption by GLUT5 can be investigated using intestinal organoids.[14][15]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Glycolysis and Gluconeogenesis edit
- ^ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000142583 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028976 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 25539725.
- PMID 9781312.
- PMID 18398011.
- PMID 19091748.
- S2CID 46770845.
- PMID 18398011.
- S2CID 13029991. Archived from the original(PDF) on September 9, 2012.
- PMID 15542355.
- ISBN 9783437420122, S. 208
- PMID 33015026.
- PMID 26582215.
External links
- GLUT5+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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